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EC number: 204-847-9
CAS number: 127-52-6
Table 1. Recovery of benzenesulfonamide in the
Duration of exposure
B was tested in vitro on full-thickness porcine skin according to OECD
TG 428 method. Disc-shaped pieces, (diameter 5cm) were defrozen prior to
testing (2-3 hours). Metabolic status was metabolically non-active. 40
µL was applied for different durations (1h, 2h, 4h, 6h, 8h and 24h). At
the end of exposure the skin surface was wiped using a metal spatula
(fraction 1), the skin preparation was then cut into small pieces
(fraction 2) and the receptor fluid was collected (fraction 3) .
application on skin, Chloramine B was not detected in any of the
analysed fractions and receptor fluid, it is not absorbed in the skin
and does not penetrate. Only the presence of its degradation product,
benzenesulfonamide, was detected in the skin fractions and receptor
fluid. After short-term exposure its penetration is negligible, after 24
h exposure its penetration is low.
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