Registration Dossier

Administrative data

Description of key information

Despite being irritating to abraded rabbit skin, lactic acid is practically non-toxic by the oral, inhalation and dermal route.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
3 543 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
7 400 mg/kg bw

Additional information

Lactic acid is a ubiquitous and essential biological molecule. It is practically non-toxic by all routes of exposure. Dermal exposure to 2000 mg/kg bw induced severe irritation, but no mortality. Oral administration of doses of 3500 mg/kg bw induced mortality, and lower doses induced clear signs of toxicity. All toxicity signs clearly point to (acid) irritation as the main or only mode of action. At 7400 mg/m³ lactic acid in air, one out of 5 female rats died in a 4 hour inhalation study. All symptoms observed in dead and surviving animals suggest (acid) irritation as the main or only mode of action.

Justification for classification or non-classification

Lactic acid is a ubiquitous and essential biological molecule. It is practically non-toxic by all routes of exposure.