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Toxicological information

Toxicity to reproduction

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Administrative data

Endpoint:
reproductive toxicity, other
Type of information:
experimental study
Adequacy of study:
other information
Study period:
1934
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Effects of feeding sodium bicarbonate or lactic acid upon the sex ratio in rats
Author:
D'Amour FE
Year:
1934
Bibliographic source:
Science 79(2038): 61-62

Materials and methods

Test animals

Species:
rat
Strain:
not specified

Administration / exposure

Route of administration:
oral: feed
Details on exposure:
Animals to be bred were placed on stock diet, which consists of a mixture of ground grains, dried milk, mineral salts and cod liver oil, with which was incorporated with either sodium bicarbonate or lactic acid.
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
Prior to breeding to parturition
Doses / concentrationsopen allclose all
Dose / conc.:
2.5 other: %
Remarks:
Percent of lactic acid in stock diet
Dose / conc.:
5 other: %
Remarks:
Percent of lactic acid in stock diet

Results and discussion

Any other information on results incl. tables

Concentration

 # litters  Males Females Total 
 2.5% lactic acid in feed  10  38 42 80 
5% lactic acid in feed  28  107 128  235 
 Total  38  145  170  315

Sex ratio (females/males) = 170 /145 = 1.17

Applicant's summary and conclusion

Conclusions:
The sex ratio of the offspring was not affected by the treatment of lactic acid.
Executive summary:

The sex ratio of the offspring was not affected by the treatment of lactic acid.