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Administrative data

Description of key information

Repeated-dose toxicity should be considered a non-relevant end point for a biochemically essential substance,

at least in the framework of normal toxicological testing.

Key value for chemical safety assessment

Mode of Action Analysis / Human Relevance Framework

Additional information

High levels of exposure to calcium lactate in the diet (up to 30% in feed) did not lead to any lactate-associated effects; all effects observed were due to the excessive intake of calcium. It could be concluded that any deleterious effects of lactic acid are caused by the effect of lactic acid on local pH, not on any biological effect of lactate.

High dermal exposure to lactate, in cosmetic creams, did not lead to any effects, with the exception of slight irritation at the highest doses.

Lactic acid is to be considered non-toxic; the only deleterious effects of lactic acid are due to local irritation as a result of decreased pH.

Justification for classification or non-classification

Lactic acid is considered to be non-toxic; the deleterious effects of lactic acid are due to local irritation as a result of decreased pH.