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Physical & Chemical properties

Solubility in organic solvents / fat solubility

Administrative data

Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1998

Materials and methods

Principles of method if other than guideline:
Making of a saturated solution of lactic acid (solid) in various solvents, and determining the concentration dissolved lactic acid after a set period of time.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
IUCLID4 Test substance: other TS: pure lactic acid

Results and discussion

Solubility in organic solvents / fat solubilityopen allclose all
Medium:
methanol
Solubility:
78.6 other: % w/w
Temp.:
20 °C
Medium:
ethanol
Solubility:
70.9 other: % w/w
Temp.:
20 °C
Medium:
other: n-propanol
Solubility:
62.4 other: % w/w
Temp.:
20 °C
Medium:
isopropanol
Solubility:
63.4 other: % w/w
Temp.:
20 °C
Medium:
n-butanol
Solubility:
54.5 other: % w/w
Temp.:
20 °C
Medium:
other: 2-ethylhexanol
Solubility:
29 other: % w/w
Temp.:
20 °C
Medium:
other: hexane
Solubility:
0.005 other: % w/w
Temp.:
20 °C
Medium:
toluene
Solubility:
0.11 other: % w/w
Temp.:
20 °C
Medium:
diethyl ether
Solubility:
38.7
Temp.:
20 °C
Medium:
other: tetrahydrofuran
Solubility:
65.1 other: % w/w
Temp.:
20 °C
Test substance stable:
yes

Applicant's summary and conclusion

Conclusions:
Lactic acid is soluble in most polar solvents, but sparingly soluble to insoluble in nonpolar solvents like hexane and toluene.
Executive summary:

The objective of this piece of research was to determine the solubility of lactic add (crystals) in a number of common organic solvents ·and Purae products. With the results the best solvent(s) could be chosen to wash lactic acid crystals. Another objective was to increase the basic knowledge on lactic acid. Results were obtained by stirring dry lactic acid crystals at a certain temperature in a solvent. After 0.75-1 hour a sample was taken and analyzed on lactic acid (free acidity). The results are for pure monomeric lactic acid, therefore the solubility for lactic acid containing oligomers and/or water can be different.

Lactic acid is soluble in most polar solvents, but sparingly soluble to insoluble in nonpolar solvents like hexane and toluene.