Registration Dossier

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Remarks:
Review Paper

Data source

Reference
Reference Type:
review article or handbook
Title:
Safety assessment of glycolic acid, ammonium, calcium, potassium, and sodium glycolate, methyl, ethyl, ptopyl, and butyl glycolate, and lactic acid, ammonium calcium, potassium, sodium, and TEA-lactate, methyl, ethyl, isopropyl, and butyl lactate, and
Author:
Andersen, F.A.
Year:
1997
Bibliographic source:
Cosmetic Ingredients Review, final report. International Journal of Toxicology, Vol.17, Suppl.1.

Materials and methods

Study type:
clinical case study
Endpoint addressed:
not applicable
Principles of method if other than guideline:
In consumer and salon use, alpha-hydroxy agents (AHAs) can function as mild exfoliants, but are also used as pH adjusters and skin-conditioning agents. In the present review toxicological studies about such use are summarized. The review includes clinical testing of skin irritation, animal metabolism and distribution studies, acute oral animal studies about the renal and nephrotoxic effects, systemic effects via dermal application, animal ocular tests, and in vitro tests to predict ocular irritation, studies about developmental and maternal toxicity.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified
Details on test material:
- Name of test material (as cited in study report): Lactic acid
Specific details on test material used for the study:
.

Results and discussion

Applicant's summary and conclusion

Conclusions:
No adverse effects on skin observed.