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Toxicological information

Specific investigations: other studies

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Reference
Endpoint:
specific investigations: other studies
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Remarks:
This is a custom literature review on the biology and (non)toxicity of D-(-)-lactic acid.
Justification for type of information:
Statement explaining why no further toxicity testing with lactic acid is required. This statement supports the submission of the available toxicity information for Lactic acid for classification and labelling of D-(-)-lactic acid, and consequently general lactic acid.
Reference:
Composition 0
Principles of method if other than guideline:
Literature review.
Type of method:
other: Literature review
Test material information:
Composition 1
Details on results:
D-(-)-lactic acid is a common biological molecule, with low acute and no chronic toxicity, to which humans are continuoualy exposed, from diet, from bacterial generation in the gut, and from intramitochondrial (innate) processes.
Conclusions:
D-(-)-lactic acid is a common biological molecule, with low acute and no chronic toxicity, to which humans are continuoualy exposed, from diet, from bacterial generation in the gut, and from intramitochondrial (innate) processes. Therefore, it is fully justified to read across from L-(+)-lactic acid toxicity data for classification and labelling purposes and to fulfil REACH data requirements.
Executive summary:

D-(-)-lactic acid is a common biological molecule, with low acute and no chronic toxicity, to which humans are continuously exposed, from diet, from bacterial generation in the gut, and from intramitochondrial (innate) processes. Therefore, it is fully justified to read across from L-(+)-lactic acid toxicity data for classification and labelling purposes and to fulfil REACH data requirements

Description of key information

D-(-)-lactic acid is a common biological molecule, with low acute and no

chronic toxicity, to which humans are continuously exposed, from diet, from bacterial generation in the gut, and from intramitochondrial (innate) processes. Therefore, it is fully justified to fulfil the requirements under REACH for the human health hazard assessment, as well as classification and labelling of D-(-)lactic acid, and hence general lactic acid, based on available toxicity information for L-(+)-lactic acid. An elaborate statement explaining why no further toxicity testing is required is attached in the present Section 7.9.3 Specific investigations: other studies.

Additional information

D-(-)-lactic acid is a common biological molecule, with low acute and no chronic toxicity, to which humans are continuously exposed, from diet, from bacterial generation in the gut, and from intramitochondrial (innate) processes. Therefore, it is fully justified to fulfil the requirements under REACH for the human health hazard assessment, as well as classification and labelling of D-(-)lactic acid, and hence general lactic acid, based on available toxicity information for L-(+)-lactic acid. An elaborate statement explaining why no further toxicity testing is required is attached in the present Section 7.9.3 Specific investigations: other studies.