Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-831-0 | CAS number: 75-01-4
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Available data indicate that vinyl chloride is absorbed rapidly and virtually completely absorbed following inhalation and oral exposure. Dermal absorption of gaseous vinyl chloride is not significant. After a 2 -2.5 h exposure of rhesus monkeys to 800 and 7000 ppm vinyl chloride, dermal absorption was estimated to be 0.031% and 0.023% of total bioavailable vinyl chloride, respectively.
In rats, absorbed vinyl chloride is distributed primarily to the liver and skin.
Metabolism is believed to proceed via different pathways, the extent of which is dependent on vinyl chloride concentrations. At low concentrations, vinyl chloride is oxidized sequentially to 2-chloroethanol, 2-chloroacetaldehyde and 2 -chloroacetic acid by alcohol dehydrogenase, while at higher concentrations it is metabolized by liver cytochrome P-450 IIE1 to the reactive oxirane, 2 -chloroethylene oxide and its rearrangement product 2-chloroacetaldehyde. Chloroethylene oxide and chloroacetaldehyde react with nucleic acid bases, forming DNA adducts, which are thought to play a role in carcinogenicity of vinyl chloride.
The elimination of vinyl chloride follows first-order kinetics. At low exposure levels, the majority is excreted into the urine, while at higher exposure levels, the proportion of exhaled unmetabolized vinyl chloride increases.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
