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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

The 96-h LC50 is 210 mg/l in the fresh water species Brachydanio rerio tested according OECD 203 (Groeneveld, 1993)

Key value for chemical safety assessment

LC50 for freshwater fish:
210 mg/L

Additional information

A GLP-compliant OECD 203 guideline test was available and the 96-h LC50 value of vinyl chloride in Brachydanio rerio is 210 mg/l (Groeneveld, 1993). This value is used in the assessment, because the other two experimental studies that are available are older non-GLP studies with higher LC50 values (Industrial Bio-Test laboratories, Inc., 1971). Furthermore, calculated effect concentrations using ECOSAR are available for freshwater fish (U.S. EPA, 2000). The calculation of 115 mg/l is reliable, validated and falls within the applicability domain of the QSAR.