Chloroethylene

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Non-GLP, non-guideline study, published in peer-reviewed literature, minor restrictions in design and reporting, but otherwise adequate for assessment.

Data source

Reference

Reference Type:

publication

Title:

Experimental acute toxicity of vinyl chloride (monochloroethene).

Author:

Prodan L, Suciu V, Pislaru V, Ilea E, Pascu L

Year:

1975

Bibliographic source:

Ann NY Acad Sci 246:154-158.

Materials and methods

Principles of method if other than guideline:

Exposure of rats for 2 h to the test substance in gas chambers according to Krakov's method

GLP compliance:

no

Test type:

other: Krakov's method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Chloroethylene

EC Number:

200-831-0

EC Name:

Chloroethylene

Cas Number:

75-01-4

Molecular formula:

C2H3Cl

IUPAC Name:

chloroethene

Details on test material:

Not reported.

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

No age, weight and source were indicated.

Administration / exposure

Route of administration:

inhalation: gas

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: gas chambers of the Pravdintype
- Exposure chamber volume: 580 l
- Gas was continuously stirred in the chamber by an inside pellet.


TEST ATMOSPHERE
- Brief description of analytical method used: volumetrically with a Zimmermann type spirometer

Analytical verification of test atmosphere concentrations:

yes

Duration of exposure:

2 h

Concentrations:

Concentrations: 15% (375.0 mg/l), 16% (400 mg/l), 17% (425.0 mg/l), 20% (500.0 mg/l), or 21% (525.0 mg/l).

No. of animals per sex per dose:

Number of animals in total = 70
Number of animals per dose: N=30, 10, 10, 10, 10, 10 for exposure to 15% (375.0 mg/l), 16% (400.0
mg/l), 17% (425.0 mg/l), 20% (500.0 mg/l) and 21 (525 mg/l), respectively

Control animals:

no

Details on study design:

Examinations performed: clinical signs, necropsy

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LC50

Effect level:

390 mg/L air (nominal)

Exp. duration:

2 h

Mortality:

Number of deaths at each dose: 375 mg/l (7/30), 400 mg/l (8/10), 425 mg/l (9/10), 500 mg/l (9/10), 525 mg/l (10/10). The majority of deaths at each dose occurred during the first hour of exposure.

Clinical signs:

other: Death of animals preceded by excitement, contractions, convulsions, and respiratory excitement followed by failure. Intensive salivation and lacrimation were noted.

Gross pathology:

Necropsy Findings: General congestion of all internal organs.

Other findings:

Potential Target Organs: Lungs, liver, kidney

Applicant's summary and conclusion

Interpretation of results:

study cannot be used for classification

Remarks:

Migrated information: based on LC50 (2hr) rat and when extrapolated with Haber's Law