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EC number: 200-831-0 | CAS number: 75-01-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, non-guideline study, published in peer-reviewed literature, minor restrictions in design and reporting, but otherwise adequate for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Experimental acute toxicity of vinyl chloride (monochloroethene).
- Author:
- Prodan L, Suciu V, Pislaru V, Ilea E, Pascu L
- Year:
- 1 975
- Bibliographic source:
- Ann NY Acad Sci 246:154-158.
Materials and methods
- Principles of method if other than guideline:
- Exposure of rats for 2 h to the test substance in gas chambers according to Krakov's method
- GLP compliance:
- no
- Test type:
- other: Krakov's method
- Limit test:
- no
Test material
- Reference substance name:
- Chloroethylene
- EC Number:
- 200-831-0
- EC Name:
- Chloroethylene
- Cas Number:
- 75-01-4
- Molecular formula:
- C2H3Cl
- IUPAC Name:
- chloroethene
- Details on test material:
- Not reported.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No age, weight and source were indicated.
Administration / exposure
- Route of administration:
- inhalation: gas
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: gas chambers of the Pravdintype
- Exposure chamber volume: 580 l
- Gas was continuously stirred in the chamber by an inside pellet.
TEST ATMOSPHERE
- Brief description of analytical method used: volumetrically with a Zimmermann type spirometer - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 2 h
- Concentrations:
- Concentrations: 15% (375.0 mg/l), 16% (400 mg/l), 17% (425.0 mg/l), 20% (500.0 mg/l), or 21% (525.0 mg/l).
- No. of animals per sex per dose:
- Number of animals in total = 70
Number of animals per dose: N=30, 10, 10, 10, 10, 10 for exposure to 15% (375.0 mg/l), 16% (400.0
mg/l), 17% (425.0 mg/l), 20% (500.0 mg/l) and 21 (525 mg/l), respectively - Control animals:
- no
- Details on study design:
- Examinations performed: clinical signs, necropsy
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 390 mg/L air (nominal)
- Exp. duration:
- 2 h
- Mortality:
- Number of deaths at each dose: 375 mg/l (7/30), 400 mg/l (8/10), 425 mg/l (9/10), 500 mg/l (9/10), 525 mg/l (10/10). The majority of deaths at each dose occurred during the first hour of exposure.
- Clinical signs:
- other: Death of animals preceded by excitement, contractions, convulsions, and respiratory excitement followed by failure. Intensive salivation and lacrimation were noted.
- Gross pathology:
- Necropsy Findings: General congestion of all internal organs.
- Other findings:
- Potential Target Organs: Lungs, liver, kidney
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information: based on LC50 (2hr) rat and when extrapolated with Haber's Law
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