Registration Dossier

Administrative data

Description of key information

The gaseous nature of vinyl chloride precludes the conduct of conventional skin and eye irritation tests in animals. 

Key value for chemical safety assessment

Additional information

In accordance to section 2 of REACH Annex XI, studies on skin and eye irritation do not need to be conducted as the substance is a gas. A review paper on vinyl chloride toxicological properties by Easter et al. (1994) states that liquid vinyl chloride would be expected to cause frostbite injury. When placed on skin or in eyes, liquid vinyl chloride may freeze tissue and produce a chemical burn as it evaporates, causing damage to the underlying tissue. This is however typical for all liquefied gases and is not substance specific.

Justification for classification or non-classification

The gaseous nature of vinyl chloride precludes the conduct of conventional skin and eye irritation tests in animals. Therefore, classification for skin and eye irritation is not applicable according to EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.