Registration Dossier

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation / corrosion
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: A review paper on physico-chemical, human toxicological and ecotoxicological properties of vinyl chloride, mentioning effect of liquid vinyl chloride on skin.

Data source

Reference
Reference Type:
publication
Title:
Toxicology Update: Vinyl Chloride.
Author:
Easter, M.D. and Von Burg, R.
Year:
1994
Bibliographic source:
J Appl Toxicol 14:301-307.

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

In vivo

Irritant / corrosive response data:
Liquid vinyl chloride would be expected to cause frostbite injury. When placed on skin, liquid vinyl chloride may freeze tissue and produce a chemical burn as it evaporates, causing damage to the underlying tissue.

Applicant's summary and conclusion