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Administrative data

Description of key information

The mouse lung adenoma assay gave no indication of carcinogenic potential. 

Key value for chemical safety assessment

Additional information

There are no reliable data available.

In en exploratory study male strain A/St mice (20 animals/group, these animals show a very high sensitivity to carcinogens resulting in short latency period and higher tumor rates) were treated by intraperitoneal injection with 20 (18 doses), 40 (3 doses) or 80 mg/kg bw (single dose) of TPP, 3 times/week and observed for a further 18 weeks. Afterwards lungs were examined for adenomas. The survival rate was 18/20 in the low dose group, 3/20 in the mid dose group and 12/20 in the high dose group. Adenomas were seen only in the high dose group with no significant increase of incidence (Theisis, 1977).

Justification for classification or non-classification

TPP shows no evidence to suggest that it has carcinogenic potential.