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Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Mixture cotaining only 35% TPP tested. Also assessed by OECD.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1987

Materials and methods

Type of study / information:
Type: adsorption
Principles of method if other than guideline:
Metabolism, in vivo: rat, single i. p. injection of 300 mg of a commercial plasticizer containing 35 % TPP and several cresylphosphate isomeres: determination of TPP in the liver and blood after 4 h and 24 h determination of induction of microsomal cytochrome P-450 in the liver, pseudocholine esterase in plasma, histopathology of caudal nerves
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

Metabolism, in vivo: 
TPP in the liver after 4 h 36.6±23.3 µg/g, after 24 h 1.8±1.9 µg/g;
in blood: TPP after 4h: 0.7+-0.3 µg/g, 24 h not detectable
induction of microsomal cytochrome P-450 in the liver,
decrease of pseudocholine esterase in plasma,
swollen myelin sheaths in caudal nerves 2 weeks after injection of 300 mg/kg.

Applicant's summary and conclusion

Executive summary:
Metabolism, in vivo: rat, single i. p. injection of 300 mg
of a commercial plasticizer containing 35 % TPP and several cresylphosphate isomeres:
determination of TPP in the liver and blood after 4 h and 24 h
determination of induction of microsomal cytochrome P-450 in the liver, pseudocholine esterase in plasma,
histopathology of caudal nerves.
Metabolism, in vivo: 
TPP in the liver after 4 h 36.6±23.3 µg/g, after 24 h 1.8±1.9 µg/g;
in blood: TPP after 4h: 0.7+-0.3 µg/g, 24 h not detectable
induction of microsomal cytochrome P-450 in the liver,
decrease of pseudocholine esterase in plasma,
swollen myelin sheaths in caudal nerves 2 weeks after injection of 300 mg/kg.