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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Exposure level lower than recommended for a limit test, chamber closed, not according to guideline, observation period inadequate. Also assessed by OECD.

Data source

Reference
Reference Type:
publication
Title:
Studies on the industrial hygiene and toxicology of triphenyl phosphate.
Author:
Sutton WL, Terhaar CJ, Miller FA, Scherberger RF, Riley EC, Roudabush RL, Fassett DW
Year:
1960
Bibliographic source:
Arch. Environ. Health 1, 45-58

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
yes
Remarks:
exposure level lower than recommended, closed chamber
Principles of method if other than guideline:
Mice exposed to TPP vapour in a battery jar.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
mouse
Strain:
CF-1
Sex:
male

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Analytical verification of test atmosphere concentrations:
not specified
Concentrations:
363 mg/m3 for 6 hours, 5 mice and 757 mg/m3 for 2 and 4 hours, 7mice/ducration
Control animals:
yes

Results and discussion

Any other information on results incl. tables

None of the animals exhibited any colinergic signs or symptoms.
No significant effects at 363 mg/m3(6h) and 757 mg/m3(4 h)
significant effect at 757 mg/m3 (2h) but with questionable biological relevance

The mice were observed for signs of cholinergic toxicity and blood chloinesterase was measured at termination but were considered not valid because controls did not appear to have been sham exposed.

Applicant's summary and conclusion

Interpretation of results:
other: practically nontoxic
Remarks:
expert judgment
Conclusions:
No overt signs of toxicity; Cholinesterase determinations not considered valid as controls did not appear sham exposed.
Executive summary:

In an acute inhalation study, mice were exposed to TPP vapour in a battery jar following generation of the vapour by flowing preheated air through molten TPP at 175 -180 deg C. Observation period was 24 hours. The mice were observed for signs of cholinergic toxicity and blood cholinesterase was measured at termination. No overt signs of toxicity; cholinesterase determinations not considered valid because the controls did not appear to be sham exposed.