Registration Dossier

Administrative data

Endpoint:
neurotoxicity, other
Remarks:
other:
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: high purity test substance, low animal number. Also assessed by OECD.

Data source

Reference
Reference Type:
publication
Title:
Does triphenyl phosphate produce delayed neurotoxic effects?
Author:
Wills JH, Barron K, Groblewski GE, Benitz KF, Johnson MK
Year:
1979
Bibliographic source:
Toxicology Letters 4(1), 21-24

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other:
Deviations:
not specified
Principles of method if other than guideline:
Neurotoxicity study in cats. Low animal number.
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
cat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
subcutaneous
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
Subcutaneous, single dose,
Frequency of treatment:
single dose
Doses / concentrations
Remarks:
Doses / Concentrations:
400, 700 and 1000 mg/kg bw
Basis:
no data
No. of animals per sex per dose:
8 animals

Results and discussion

Any other information on results incl. tables

OBSERVATION: 
400 mg/kg bw: no ataxia
700 mg/kg bw: weight loss, prostration, diarrhea
1000 mg/kg bw: weight loss, prostration,
Histopathology (700 mg/kg): generalized vascular damage, perivascular edema, loss of colon epithelium, fatty change in the liver

HISTOPATHOLOGY OF NERVOUS TISSUES:
no axon degeneration or demyelination or any other pathological change at any dose level.

Applicant's summary and conclusion

Conclusions:
There was weight loss at the mid and high dose groups but not evidence of neurotoxicity following histological examination of nervous tissues.
Executive summary:

Cats administered s.c single dose of TPP (400, 700, 1000 mg/kg bw) exhibited the following:

OBSERVATION: 
400 mg/kg bw: no ataxia
700 mg/kg bw: weight loss, prostration, diarrhea
1000 mg/kg bw: weight loss, prostration,
Histopathology (700 mg/kg): generalized vascular damage, perivascular edema, loss of colon epithelium, fatty change in the liver
HISTOPATHOLOGY OF NERVOUS TISSUES:
no axon degeneration or demyelination or any other pathological change at any dose level.