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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: case report. No details about exposure concentrations and duration. Also assessed by OECD.

Data source

Reference
Reference Type:
publication
Title:
Contact dermatitis from plastic containing triaryl phsophates.
Author:
Pegum JS
Year:
1966
Bibliographic source:
Brit. J. Derm. 78: 626-631

Materials and methods

Type of sensitisation studied:
skin
Study type:
case report
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
No data
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Triphenyl phosphate
EC Number:
204-112-2
EC Name:
Triphenyl phosphate
Cas Number:
115-86-6
Molecular formula:
C18H15O4P
IUPAC Name:
triphenyl phosphate

Method

Type of population:
not specified
Ethical approval:
not specified
Subjects:
- Number of subjects exposed: 1
- Other: no other data
Clinical history:
- History of allergy or casuistics for study subject or populations: dermatitis
no other data
Route of administration:
dermal
Details on study design:
One person with mutiple causes producing dermatitis was patched with TPP and other aryl phosphates.

Results and discussion

Results of examinations:
Person tested positive to all patches.

Applicant's summary and conclusion

Conclusions:
Positive to all patches.
Executive summary:

One person with multiple causes producing dermatitis was patched with TPP and other aryl phosphates. The person tested positive to all patches.