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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Short report, few details. Also assessed by OECD

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Principles of method if other than guideline:
Method: other: as described in 16 CFR 1500.40
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit
Strain:
other: Albino
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
This study was conducted according to US Federal Hazardous Substances Act Regulations study guideline 16 CFR 1500.40. 5 rabbits were tested with intact skin and 5 with abraded skin. Observation period of 14 days.
Doses:
10000 mg/kg
No. of animals per sex per dose:
10

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 10 000 mg/kg bw
Mortality:
None
Clinical signs:
No data
Body weight:
No data
Gross pathology:
No data

Any other information on results incl. tables

MORTALITY: none

Applicant's summary and conclusion

Interpretation of results:
not classified
Conclusions:
Dermal LD50 is > 10,000 mg/kg body weight.
Executive summary:

2 groups of 5 albino rabbits were treated each with a dose of 10 000 mg/kg body weight on either intact or abraded skin. No adverse effects nor mortality were observed during 14 -days post-exposure. The LD50 is >10,000 mg/kg body weight.