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Description of key information

Key value for chemical safety assessment

Additional information

An OECD guideline study (404) showed after an exposure period of 3 hours slight to moderate erythema as well as slight edema. After an exposure period of 1 h our slight to marked erythema and after 4 hours slight to moderate erythema were observed. In an EpiDerm test in vitro a corrosive potential of the test substance was seen (BASF, 2003).

An in vitro eye irritation test (HET-CAM) showed serious eye damage (BASF, 2006). This was in concordance with an older BASF in vivo study (1966), where severe irritating eye effects were found.


Effect level: empty Endpoint conclusion: Adverse effect observed

Effect level: empty Endpoint conclusion: Adverse effect observed

Justification for classification or non-classification

Classification proposal: R 38 and R 41.