Registration Dossier
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EC number: 203-631-1 | CAS number: 108-94-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
With high probability acute not harmful to aquatic invertebrates
Key value for chemical safety assessment
Additional information
Two publications by Bringmann and Kuehn (1982, 1977) indicate that cyclohexanone is acute not harmful to Daphnia. The 24h-EC50 values are 800 mg/L and 820 mg/L, respectively. Both studies were performed similar to German industrial standard, with a test period of 24 h and without analytical controls. Nevertheless these limitations were considered in a validity score of 2 (valid with restrictions), which is in the line with the validation in the ICCA SIDS program. The validity without analytical monitoring is reasonable, since cyclohexanone can be supposed as stable under the test conditions and the volatilization of cyclohexanone is negligible. Cyclohexanone has a Henry’s Law constant of 1.3 Pa/m³ mol and has therefore a low tendency to escape from the awter phase.
These results are confirmed by a read across to the structural analogue substance cyclopentanone. For cyclopentanone a GLP guideline study with analytical controls is available (L'Haridon, 2003). At the end of the test duration the recovery rate of the test item was > 80 %. Cyclopentanone has an estimated Henry`s Law constant of 0.92 Pa/m³ mol. Therefore volatilisation can be excluded under this test conditions. After 48 hours exposition to cyclopentanone no immobilisation of Daphnia magna was observed up to the highest test concentration of 100 mg/L.
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