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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Description of key information

Cyclohexanone has a low chronic toxicity to aquatic invertebrates.

No experimental data on long-term toxicity to aquatic invertebrates are available. A NOEC (21 d) of 26.6 mg/L for reproduction in Daphnia magna was estimated using the QSAR Toolbox v4.3.1 . The prediction is based on trend analysis of 26 values from similar chemicals (category approach).

The result is derived from a valid QSAR model and falls into its applicability domain. It is considered therefore reliable to cover the endpoint and is taken as key value for the chemical safety assessment.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
26.6 mg/L

Additional information

In Annex IX of Regulation (EC) No 1907/2006 it is laid down that long-term toxicity to aquatic invertebrates shall be proposed by the registrant if the chemical safety assessment indicates the need to investigate further the effects on aquatic invertebrates. According to Annex I of this regulation, the chemical safety assessment triggers further action when the substance or the preparation meets the criteria for classification as dangerous according to Directive 67/548/EEC or Directive 1999/45/EC or is assessed to be a PBT or vPvB. The hazard assessment of cyclohexanone reveals neither a need to classify the substance as dangerous to the environment, nor is it a PBT or vPvB substance, nor are there any further indications that the substance may be hazardous to the environment. Therefore, an experimental study on long-term toxicity test in aquatic invertebrates is considered scientifically not justified.