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Toxicological information

Neurotoxicity

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Evaluation of the specified tissues of the nervous system of untreated control and and 1000 ppm F1a progeny selected for neurotoxicologic testing did not reveal lesions in any of the tissues. Microscopic examinations of the eyes from the F1a progeny revealed lenticular vacuolation (vacuolation of a few outer cortical fibers in the lens) for 2/115 of the 500 ppm progeny and 3/114 of the 1000 ppm progeny (ABC, 1986).