Registration Dossier
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EC number: 203-631-1 | CAS number: 108-94-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: basic information given
Data source
Reference
- Reference Type:
- publication
- Title:
- Uptake, metabolism and elimination of cyclohexanone in humans.
- Author:
- Mraz, J., Galova, E., Nohova, H.
- Year:
- 1 994
- Bibliographic source:
- Int. Arch. Environ. Health 66, 203-208
Materials and methods
- Objective of study:
- other: metabolism and toxicokinetic
- Principles of method if other than guideline:
- The goal of this study was to obtain, under well-defined experimental conditions, sufficient data on the metabolism and elimination of CH-one in humans for the development of a new biological exposure test.
- GLP compliance:
- not specified
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Radiolabelling:
- no
Test animals
- Species:
- human
- Sex:
- male/female
Administration / exposure
- Route of administration:
- other: percutaneous and inhalative
- Details on exposure:
- Percutaneous absorption:
A vessel containing pure CH-one liquid (22°C) was placed in a fume hood and the volunteer immersed his or her dry left hand in CH-one up to the wrist. After 30 min, the volunteer took the hand out of the CH-one, washed it thoroughly with warm water and saop and applied a protective cream. Urine was then collected for the subsequent 72 h and analysed for 1,2-CH-diol. The permeation rate of CH-one through skin was calculated.
Inhalation exposures:
The exposure experiments were conducted in groups of 3 or 4 subjects in a closed exposure chamber (volume 64m3), with the required concentration of vapour maintained by the method of Sedivic et al. In principle, a calculated amount of liquid CH-one was evaporated before the exposure, and further vapour supply was controlled by feedback from a Carlo erba gas chromatograph equipped with an automatic gas smapling valve, and analysing at atmosphere at 5-min intervals. Analyses ere performed on a stainless steel column filldd with 20% Carbowax 20M on silanized Gas Chrom P and operated at 100°C. The difference between the prepared and rquired vapour concenetration was always below 5%. The coefficient of variation of concentration measurements during the exposures was from 4% to 8%. Mean temperature and relative humidity during the exposures were 26°C and 70%, respectively.
All exposures were conducted over a period of 8 hours. In addition to single-day exposures with 8 subjects, 4 persons were exposed to CH-one, ca. 200 mg x m-3, for 5 consecutive days, 8 h/day. Volunteers were at rest during the exposure experiments. They left the exposure chamber at 2-h intervals for 2-3 min to void urine. - Duration and frequency of treatment / exposure:
- see details on exposure
Doses / concentrations
- Remarks:
- Doses / Concentrations:
see details on exposure
- No. of animals per sex per dose:
- 4 male and 4 female humans
Results and discussion
Any other information on results incl. tables
Percutaneous absorption: Percutaneous absorption of CH-one was assessed in an experiment in which subjects immersed one hand in pure solvent for 30 min. The total amounts of 1.2-CH-diol excreted during the following 72 h were 25 - 63 umol (mean 45 umol). The permeation rate of CH-one through the skin of the hand, as calculated from these date, was 0.037 - 0.969 mg x cm-2 x h-1 (mean 0.056 mg x cm-2 x h-1).
Inhalation: The metabolites CH-ol, 1,2 -CH-diol and 1,4 -CH-diol were monitored in urine voided during a 72-h period following the 8 -h exposure of volunteers to CH-one vapour at a concentration of 101 -406 mg x m-3. The analytical procedure conjugates and therefore each compound determined represents the sum of its conjugated and unconjugated forms. Whereas CH-ol in urine accounted for barely 1% of the absorbed doses, .2 -and 1.4-CH-diol were the major metabolites of CH-one. Parent CH-one was not detected in urine. Within the range of exposures to CH-one, 101 - 406 mg x m-3, the metabolic yields of CH-ol and CH-diols were effectively constant. Similarly invariable was the character of the mean urinary excretion curves, as typified by the results for the medium exposure (207 mg x m-3). Peak excretion of CLH-ol was always achieved at the end of the exposure period, after which it decayed rapidely. The excretion curves for 1.2- and 1.4 -CH-diol reached their peaks a few hours postexposure, with subsequent elimination half-lives of 15.7 +/- 2.2 and 18.3 +/- 3.5 h, respectively. With repeated exposure to CH-one vapour for 5 consecutive days there was no cumulation of urinay CH-ol whereas cumulation of CH-diols was observed, which reflects the half-lives of the individual metabolites. The maximum excretion rates of CH-diols on days 2 and 3 of the repeated exposure were higher by approx. 30% and 50%, respectively, than the values found on day 1.
Applicant's summary and conclusion
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