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EC number: 232-188-7 | CAS number: 7789-75-5
The test substance did not induce a relevant increase in the number of revertant colonies, in either of two independent experiments (standard plate test and preincubation test) with and without S9 mix.
Calcium fluoride was evaluated for its mutagenic potential in Salmonella typhimurium strains TA1535, TA100, TA98, TA1537 and E. coli WP2 uvrA. Two independent experiments were performed in the presence and absence of metabolic activation (S9 mix); the standard plate test and the preincubation method. Appropriate negative, vehicle and positive controls were also included.
A bacteriotoxic effect, indicated byt the decreased numbers of revertants, was occasionally observed at concentrations of 2500 µg/plate and above. The test substance did not induce a relevant increase in the number of revertant colonies, in either of the two independent experiments with and without S9 mix.
Under the conditions of the study, it was concluded that Calcium fluoride is not mutagenic in the bacterial reverse mutation test in the presence and absence of metabolic activation.
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