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EC number: 232-188-7 | CAS number: 7789-75-5
Sediment toxicity
Administrative data
Link to relevant study record(s)
- Endpoint:
- sediment toxicity: long-term
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- The read-across justification is included in section 13.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 10 d
- Dose descriptor:
- other: IC10
- Effect conc.:
- < 8.42 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Remarks:
- CaF2
- Basis for effect:
- other: growth
- Duration:
- 10 d
- Dose descriptor:
- other: IC20
- Effect conc.:
- 16.84 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Remarks:
- CaF2
- Basis for effect:
- other: growth
- Key result
- Duration:
- 10 d
- Dose descriptor:
- other: IC50
- Effect conc.:
- 76 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Remarks:
- CaF2
- Basis for effect:
- other: growth
- Key result
- Duration:
- 10 d
- Dose descriptor:
- LC50
- Effect conc.:
- 112.56 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Remarks:
- CaF2
- Basis for effect:
- mortality
- Validity criteria fulfilled:
- yes
- Conclusions:
- The sub-chronic (10-d) exposure of larval Chrionomid dilutus to NaF in a sediment toxicity study shows that the IC10 is <4.1 mg/L F- and the LC50 is 54.8 mg/L F-. Using the molecular weight information, this is converts to IC10 <8.42 and LC50 = 112.56 mg/L CaF2.
- Executive summary:
A sub-chronic sediment toxicity study has been carried out according to Canadian standards (EPS 1/RM32, test for survival and growth in sediment using larvae of freshwater midges. In this study, Chironomid dilutus was exposed to fluoride spiked water for 10 days and the effect on survival and growth (dry weight) has been assessed. The sediment used was uncontaminated sand from a beach in southern British Colombia, Canada.
The IC10 was <4.1 mg/L F and the LC50 is 54.8 mg/L fluoride.
Using the molecular weight information, this is converts to IC10 <8.42 and LC50 = 112.56 mg/L CaF2.
- Endpoint:
- sediment toxicity: long-term
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- 2014
- Justification for type of information:
- The read-across justification is provided in section 13
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 14 d
- Dose descriptor:
- other: IC10
- Effect conc.:
- >= 3.7 - <= 10.68 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Remarks:
- CaF2
- Basis for effect:
- other: inhibition
- Duration:
- 14 d
- Dose descriptor:
- other: IC20
- Effect conc.:
- >= 5.13 - <= 13.56 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Remarks:
- CaF2
- Basis for effect:
- other: inhibition
- Key result
- Duration:
- 14 d
- Dose descriptor:
- other: IC50
- Effect conc.:
- >= 8.42 - <= 19.51 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Remarks:
- CaF2
- Basis for effect:
- other: inhibition
- Key result
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- >= 9.86 - <= 26.5 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Remarks:
- CaF2
- Basis for effect:
- mortality
- Validity criteria fulfilled:
- yes
- Conclusions:
- The long-term exposure of Hyalella Azteca in a sediment toxicity study to NaF shows that the IC10 varies between 1.8 and 5.2 mg/L F- (depending on the Cl- concentration) and the LC50 varies between 4.8 and 12.9 mg/L F- (depending on the Cl- concentration).
Converting the LC50 to CaF2 (using the molecular weight info), the LC50 values ranged from to 9.86 to 26.5 mg/L CaF2. - Executive summary:
A chronic sediment toxicity study has been carried out according to Canadian standards (EPS 1/RM33, test for survival and growth in sediment using the freshwater amphipod Hyalella azteca). In this study, Hyalella azteca was exposed to fluoride (NaF) spiked water for 14 days and the effect on survival and growth (dry weight) has been assessed. The sediment used was uncontaminated sand from a beach in southern British Colombia, Canada. The fluoride concentrations tested were 2, 6 and 8 mg/L. The test concentration was confirmed analytically. Simultaneously, the effect of Cl- on fluoride toxicity has been assessed (2, 6 and 18 mg/L Cl-).
If was found that the toxicity of fluoride decreases with increasing chloride concentrations.
The IC10 was 1.8 to 5.2 mg/L F, with the highest IC10 value found at the highest Cl- concentration. The IC50 is 4.1 to 9.5 mg/L F- and the LC50 is 4.8 - 12.9 mg/L fluoride.
Converting the effect values to CaF2, using the molecular weight info, this relates to:
IC10 of 3.7 to 10.68 mg/L CaF2, IC50 of 8.42 to 19.51 mg/L CaF2 and LC50 of 9.786 to 26.5 mg/L CaF2.
Referenceopen allclose all
Results chronic study
| Cl (mg/L) | Hardness (mg/L CaCO3) | IC10 (mg/L F) | IC20 (mg/L F) | IC50 (mg/L F) | LC50 (mg/L F) |
| 2 | 90 | 1.8 | 2.5 | 4.1 | 4.8 |
| 6 | 88 | 3.8 | 4.7 | 6.5 | 8.6 |
| 18 | 88 | 5.2 | 6.6 | 9.5 | 12.9 |
Description of key information
Pearcy et al. (2015) assessed the toxicity of NaF to sediment organisms Hyalella azteca and larval Chironomid dilutus. In both (sub-)chronic assessments, the organisms were exposed to spiked water (replaced 3 times per week). The exposure time was 14d and 10d respectively and the study was conducted according to the Canadian Environment standards.
The IC10 (growth) concentrations (converted to CaF2 based on molecular weight) were:
- Hyalella: 3.7 to 10.68 mg/L CaF2 (increasing IC10 with increasing on Cl concentration)
- Chironomid: < 8.42 mg/L CaF2
The LC50 valu(converted to CaF2) were:
- Hyalella: 9.86 - 26.5 mg/L CaF2
- Chironomid: 112.56 mg/L CaF2
The key values could not be expressed in mg/kg sediment.
Key value for chemical safety assessment
Additional information
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