Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 232-188-7 | CAS number: 7789-75-5
Toxicity to birds
Administrative data
Link to relevant study record(s)
Description of key information
Various studies are summarised in the WHO (2002) review. In feeding studies with different bird species, thicker egg shells, depressed weight gain and increased mortality rate was observed.
For Sturnus vulgaris, intubated with fluoride doses up to 160 mg F-/kg bw for 16 days, a NOEC of 10 mg F-/kg bw was derived for mortality and LD50 was calculated to be 17 mg F-/kg bw. Using the molecular weight of CaF2, this translated to a NOEC of 20.5 mg CaF2/kg bw for mortality and 34.9 mg/kg bw CaF2 for LD50.
Key value for chemical safety assessment
- Short-term EC50 or LC50 for birds:
- 34.9 mg/kg food
- Long-term EC10, LC10 or NOEC for birds:
- 20.5 mg/kg food
Additional information
The World Health Organisation reviewed several studies that investigated fluoride toxicity in birds.
In birds, the 24-h LD50was 50 mg/kg body weight for 1-day-old European starling (Sturnus vulgaris) chicks and 17 mg/kg body weight for 16-day-old nestlings. Growth rates were significantly reduced at 13 and 17 mg fluoride/kg body weight (the highest doses at which growth was monitored).
Kestrels were fed a diet to which flour contaminated with fluoride (10, 50 or 500 mg/kg) had been applied. The birds receiving the highest fluoride dose died within 6 days. Fluoride at the lower doses had no effect on clutch size, hatchability or fledging success but was associated with a higher fertility. Eggs laid by kestrels at 50 mg/kg had significantly thicker shells. Lower reproductive success of eastern screech-owls (Otus asio) was noted when birds were fed 90 mg fluoride/kg diet wet weight (as sodium fluoride), but not when fed 18 mg fluoride/kg diet
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
