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Administrative data

Key value for chemical safety assessment

Additional information

Genetic toxicity in vitro

No evidence of mutagenicity was reported in a modern Ames test performed with calcium difluoride (Schulz & Landsiedel, 2010) in Salmonella typhimurium strains TA1535, TA100, TA98, TA1537 and in E. coli strain WP2 uvrA. No evidence of mutagenicity was observed in a recent mammalian cell gene mutation assay (V79/HPRT) performed with calcium difluoride (Wollny, 2010).

No evidence of cytogenicity was seen in V79 cells in a modern study (Hall, 2010).

In vivo data are not required on the basis that the in vitro studies all gave negative results.

Short description of key information:
A negative Ames test, a negative study of cytogenicity in V79 cells in vitro and a negative study of gene mutation in V79 cells in vitro are available for calcium difluoride.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

No classification is proposed for genetic toxicity according to the CLP Regulation (1272/2008/EC). The available data indicate that calcium difluoride is not mutagenic.