Registration Dossier
Registration Dossier
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EC number: 232-188-7 | CAS number: 7789-75-5
Specific investigations: other studies
Administrative data
Link to relevant study record(s)
Description of key information
Data indicate that calcium fluoride dust may cause local effects in the lung following inhalation.
Additional information
Xu et al (1986) investigated the pathogenicity of mixed dust from a fluorite mine in animal experiments and in vitro tests . Animal experiments showed that calcium fluorite induced a foreign body reaction in the lungs; the fibrous nodular lesions induced by the fluorite mine dust were due mainly to its silica component. It was demonstrated that either silica or the mixed dust of a fluorite mine can stimulate pulmonary alveolar macrophages (PAMs) to release fibrogenetic factors in vitro, but calcium fluorite cannot . It was also demonstrated that having engulfed calcium fluorite, silica, or fluorite mine mixed dust, PAMs release an elastase- active substance . The authors suggest that the emphysematous lesion seen in autopsy material of pneumoconiosis of fluorite mine workers may be caused by calcium fluorite and silica.
King et al (1958) injected calcium fluoride dust of 1 µm mean diameter as a suspension (in saline) into the lungs of rats. Rats were sacrificed and lung histopathology was carried out at various intervals up to 1 year post-exposure. The lungs of rats that died were also examined. Calcium fluoride dust was toxic to lung cells, especially during the early stages of the study, leading to extensive necrosis. Calcium fluoride was fibrogenic, but not as strongly fibrogenic as quartz.
Kuang et al (2017) administered aqueous solutions of NaF to mice via oral gavage for a period of 42 days. The authors examined the effect of NaF on the splenic development specifically. Their findings include decreasing GI values, histopathological lesions, arresting cell cycle, and reducing T cells and B cells as well as immunoglobulin contents. It is noted that the dose level is above the NOAELs determined for dental effects (see repeated dose tox section).
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