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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
Report in japanese language available
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
GLP compliance:
yes
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
- Purity: 98.2 %
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
0.42
Temp.:
25 °C
pH:
>= 5.9 - <= 6.1
Conclusions:
The log Pow was determined to be 0.42 at 25 deg C.
Executive summary:

The octanol-water partition coefficient of 2-hydroxyethyl methacrylate was tested in a shake flask test acc. OECD 107 under GLP conditions. The log Pow was determined to be 0.42 at 25 °C.

Description of key information

The log Kow of HEMA is 0.42 (OECD Guideline 107 / shake flask method)

Key value for chemical safety assessment

Log Kow (Log Pow):
0.42
at the temperature of:
25 °C

Additional information

Additional information of a log Pow measured by shake flask method (Tanii, 1982) is available and reported to be 0.47 at room temperature. The log Pow calculated with EPI Suite v4.11 is 0.30.