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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
09.12.2005 – 09.12.2005
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
adopted on 27 July 1995
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
Directive 92/69/EEC, Official Journal L 383 A 1992
Principles of method if other than guideline:
- Principle of test: The vapour pressure is determined by measuring the boiling temperature of the substance at various specified pressures between roughly 10 to approx. 103 hPa. The apparatus consists of a tube with a boiling section (by electrical heating) in the lower part, a cooler in the middle part, and an outlet to a pressure regulation system in the upper part. The thermometer is placed in the vapour above the surface of the liquid. The temperature of the vapour is measured as a function of the pressure.
- Short description of test conditions: Glass apparatus with sample container, electrical heating device, cooler connected to a pressure regulating system .
Initial pressure: 6.0 hPa
Final pressure: 1025.3 hPa
- Parameters analysed: boiling temperature at different defined vapor pressures, followed by calculation of the vapour pressure at 20 °C acc. Clausius Clapeyron equation.
GLP compliance:
yes
Type of method:
dynamic method
Specific details on test material used for the study:
Supplier: Röhm GmbH, Darmstadt, Germany
Purity: 98.84 %
Batch No. 1035092208
Key result
Temp.:
20 °C
Vapour pressure:
0.08 hPa
Remarks on result:
other: The vapor pressure of 2-Hydroxyethylmethacrylate at 20 °C was calculated  by mathematical extrapolation using the Antoine equation. based on a measured vapor pressure curve.

Vapor pressure       Boiling temp.     Inverse temp.
    [hPa]              [°C]             * 1000
                                         [KE-1]
--------------------------------------------------------
    6.0                86.6             2.7797
   10.3                94.9             2.7170
   19.8               106.3             2.6354
   38.9               119.3             2.5481
   80.9               134.5             2.4531
  151.7               150.2             2.3621
  266.6               165.7             2.2787
  490.9               184.8             2.1836
  747.0               199.3             2.1166
 1025.3               211.5             2.0633
   47.8               122.8             2.5256
--------------------------------------------------------

Conclusions:
The vapor pressure was calculated by mathematical extrapolation using the Clausius Clapeyron equation to be 0.08 hPa at 20 deg C.
Executive summary:

The vapour pressure of 2-Hydroxyethyl methacrylate was determined by measuring the vapour pressure curve acc. OECD 104 between 86.6 and 211 °C . The vapour pressure at 20 °C was calculated using the Clausius Clapeyron equation and determined to be 0.08 hPa @ 20 °C.

Description of key information

The vapour pressure of HEMA is 0.08 hPa at 20°C (OECD guideline 104/EU test method A.4; dynamic method).

Key value for chemical safety assessment

Vapour pressure:
0.08 hPa
at the temperature of:
20 °C

Additional information

The test result is confirmed by the calculated vapour pressure of hydroxypropyl methacrylate with EPI Suite 4.1. The calculated mean vapour pressure acc. Antoine & Grain method is 0.046 hPa @ 25 °C based on a measured boiling point of 213 °C (Röhm 2007).