Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 212-782-2 | CAS number: 868-77-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- other: Case study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Documentation sufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Contact dermatitis and gastrointestinal symptoms from hydroxyethylmethacrylat
- Author:
- Mathias C.G.T., Cadwell T.M., Maibach H.I.
- Year:
- 1 979
- Bibliographic source:
- British Journal of Dermatology 100: 447-449
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- case report
- Principles of method if other than guideline:
- Case study. Patch testing done to determine cross reactivity
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-hydroxyethyl methacrylate
- EC Number:
- 212-782-2
- EC Name:
- 2-hydroxyethyl methacrylate
- Cas Number:
- 868-77-9
- Molecular formula:
- C6H10O3
- IUPAC Name:
- 2-hydroxyethyl methacrylate
- Details on test material:
- - Name of test material (as cited in study report): hydroxyethylmethacrylate
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- not specified
- Subjects:
- - Number of subjects exposed: 1
- Sex: Male
- Age: 28
- Race: Black
- Other: laboratory technician - Clinical history:
- - Symptoms, onset and progress of the disease: three separate outbreaks occurred, at approximately 2 month intervals, each progressively worse. Characterized by nausea, and diarrhoea and persistent paresthesiac of the fingertips.
- Exposure history: working with 80% hydroxyethylmethacrylate in absolute alcohol - Controls:
- Control was used in the vinyl glove patch test
- Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: patch test (epicutaneous test)
Patch tests were perfromed to a routine screening series and to a 5% dilution of HEMA in absolute alcohol; results were graded according to the standards of the International contact Dermatitis Research group.
To determine cross reactivity, patch tests containing 5% concentrations in petrolatum of methyl-, ethyl-, propyl-, isopropyl-, butyl-, and isobutylmethacrylate were performed.
To determine the ability of vinyl gloves to protect against allergic contact derematitis, further patch tests were performed with HEMA, placing a 4 x 4 cm square piece of a disposable vinyl medical examining glove between the skin and the patch.
Results and discussion
- Results of examinations:
- HEMA produced a 2 + spreading reaction at 48 and 96 h. The patient noted nausea and mild diarrhoea commencing within 4 hours of initial application of patch tests and persisting for 24 h.
Cross reactions occured to methy-, ethyl-, propyl- and isopropyl methacrylate but not to butyl- or isobutyl meth-acrylate. The methy-, ethyl-, propyl- and isopropyl methacrylate esters produced 2+ spreading reactions at 48 and 96 h. The patient experienced similar nausea and diarrhoea, commencing 4 hours after application and lasting 24 h.
Both the vinyl examining glove and latex surgical control glove produced 2+ spreading reactions by 48 h. The patient experienced nausea and diarrhoea a third time. Patch tests to 5 % hydroxyethyl methacrylate in absolute alcohol in seventeen consecutive controls were negative. None developed nausea or diarrhoea.
Applicant's summary and conclusion
- Executive summary:
A laboratory technician developed allergic contact dermatitis to HEMA associated with nausea, diarrhoea and persistent paresthesiae of the fingertips. The gastrointestinal symptoms were reproduced by patch testing. HEMA was demonstrated to pass through vinyl gloves. Cross reactions occured to methyl-, ethyl-, propyl- and isopropylmethacrylate but not butyl- or isobutylmethacrylate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.