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Endpoint:
endocrine system modulation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Principles of method if other than guideline:
The ERE-CALUX bioassay was used to determine the estrogenic activity of the compounds. This is a bioanalytical tool that uses a human breast cancer cell line, which is stably transfected with an ER responsive luciferase reporter gene (VM7Luc4E2). 17β-Estradiol (E2) was used as a reference standard.
GLP compliance:
not specified
Type of method:
in vitro
Conclusions:
HEMA showed no estrogenic activity under the conditions of this assay.
Endpoint:
endocrine system modulation
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Screening test.
Details on study design:
Type: other: estrogenic activity


2-HEMA did not show any estrogenic activity at concentrations between  10E-7 and 10E-3 M.

Description of key information

In severals screening tests 2-HEMA did not show any estrogenic activity at concentrations between  10E-7 and 10E-3 M.

Additional information