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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Adequacy of study:
other information

Data source

Reference
Title:
No information
Author:
Mir G.N., Lawrence W.H., Autian J.; Toxicological and|Pharmacological Actions of Methacrylate Monomers I: Effects|on Isolated, Perfused Rabbit Heart; Journal Pharmaceutical|Sciences 62: 778-782 (1973)

Materials and methods

Type of study / information:
Type: other

Test material

Constituent 1
Chemical structure
Reference substance name:
2-hydroxyethyl methacrylate
EC Number:
212-782-2
EC Name:
2-hydroxyethyl methacrylate
Cas Number:
868-77-9
Molecular formula:
C6H10O3
IUPAC Name:
2-hydroxyethyl methacrylate

Results and discussion

Any other information on results incl. tables

In in vitro examinations the activity upon the isolated,
perfused rabbit heart in the perfusing fluid at 
concentrations of 1:1000, 1:10000 and 1:100000 (v/v) was 
investigated. The compound reduced the heart rate and force
of contraction and increased the coronary flow rate.
2-Hydroxyethyl methacrylate produced an irreversible effect
on the isolated heart at the 1:1000 concentration but not 
at lower concentrations.

Applicant's summary and conclusion