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Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
repeated dose toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: acceptable documented publication

Data source

Referenceopen allclose all

Title:
No information
Author:
DOW Chem. Co (1977), Subchronic Toxicity study of inhaled|1.2.4-trichlorobenzene in rats, NTIS/OTS 84003A, Doc ID.|87821105
Title:
No information
Author:
Watanabe, P.G. et al. (1978): Toxicol. Appl. Pharmacol. 45,|332 - 333

Materials and methods

Principles of method if other than guideline:
Method: other: 26 females/10 males/dose group, interim kill at 0.5, 1, 2, 3 months, gross necropsies
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IUCLID4 Test substance: other TS: purity: 99.6 %

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
inhalation
Duration of treatment / exposure:
90 days
Frequency of treatment:
6 hours/day, 5 days/week
Doses / concentrations
Remarks:
Doses / Concentrations:
3 or 10 ppm (24 or 80 mg/m3)
Basis:

Control animals:
yes, concurrent no treatment
Details on study design:
Post-exposure period: 2 to 4 months

Results and discussion

Effect levels

Dose descriptor:
NOAEL
Effect level:
3 ppm
Sex:
male/female

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

migrated dataset

Applicant's summary and conclusion