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Environmental fate & pathways

Hydrolysis

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Administrative data

Endpoint:
hydrolysis
Type of information:
other: EU Risk Assessment
Adequacy of study:
other information
Reliability:
other: EU Risk Assessment
Rationale for reliability incl. deficiencies:
other: No reliability is given as this is a summary entry for the EU RAR.

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Unnamed
Year:
2003
Reference Type:
study report
Title:
Unnamed
Year:
1986
Reference Type:
review article or handbook
Title:
Handbook of environmental fate and exposure data for organic chemicals. Vol.1: Large production and priority pollutants.
Author:
Howard
Year:
1989
Bibliographic source:
Lewis Publ. Inc. Michigan.
Reference Type:
publication
Title:
Steps towards environmental hazard assessment of new chemicals (including a hazard ranking scheme, based upon directive 79/831/EEC).
Author:
Schmidt-Bleek F et al.
Year:
1982
Bibliographic source:
Chemosphere, 11(4), 383-415.

Materials and methods

Principles of method if other than guideline:
EU Risk Assessment
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

EU Risk Assessment (2003):

EU RAR, page: 24

Based on the experimental data (Korte and Freitag, 1986) on hydrolysis at 50°C,1,2,4-TCB is not expected to hydrolyse under normal environmental conditions (Howard, 1989; Schmidt-Bleek et al., 1982).

EU RAR, page: 8

The hydrolysis was studied in buffer solutions at pH 3, 7 and 9 using radioactive 1,2,4-TCB at the initial concentration of 17.7 mg/l. During a study period of 5 days, the half-lives of 1,2,4 TCB at 50°C were estimated to be 1,806 hours (75 days) at pH 3, 4,577 hours (190 days) at pH 7 and 6,889 hours (287 days) at pH 9 (Korte and Freitag, 1986). The large half-lives for hydrolysis which indicate hydrolytic stability mean that it has not been taken into account in the risk assessment.

Applicant's summary and conclusion