1,2,4-trichlorobenzene

Bioaccumulation: aquatic / sediment

Administrative data

Endpoint:

bioaccumulation in aquatic species: fish

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: OECD-Guideline study with acceptable restrictions.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1984

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 305 C (Bioaccumulation: Test for the Degree of Bioconcentration in Fish)

Deviations:

yes

Remarks:

1.) concentration of test substance differed more than 20% of the mean of the measured values 2.) the lipid content of fish was only determined at the end of the test

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

1,2,4-trichlorobenzene

EC Number:

204-428-0

EC Name:

1,2,4-trichlorobenzene

Cas Number:

120-82-1

Molecular formula:

C6H3Cl3

IUPAC Name:

1,2,4-trichlorobenzene

Details on test material:

- Name of test material (as cited in study report): 1,2,4-Trichlorbenzol
- Analytical purity: 98,1 %
- Impurities (identity and concentrations): no data

Radiolabelling:

no

Test organisms

Test organisms (species):

Cyprinus carpio

Study design

Route of exposure:

aqueous

Test type:

flow-through

Water / sediment media type:

natural water: freshwater

Total exposure / uptake duration:

56 d

Test conditions

Nominal and measured concentrations:

theoretic concentration in test chamber [mg/l] measured concentration in test chamber [mg/l]
0 (control) 0
0,01 0,00365
0,1 0,04165

Results and discussion

Bioaccumulation factor

Bioaccumulation factor 1

Type:

BCF

Value:

830

Basis:

whole body w.w.

Remarks on result:

other: Conc.in environment / dose:0,004 mg/l

Bioaccumulation factor 2

Type:

BCF

Value:

805

Basis:

whole body w.w.

Remarks on result:

other: Conc.in environment / dose:0,04 mg/l

Bioaccumulation factor 3

Type:

BCF

Value:

17 303

Basis:

total lipid content

Remarks on result:

other: Conc.in environment / dose:0,004 mg/l

Bioaccumulation factor 4

Type:

BCF

Value:

16 779

Basis:

total lipid content

Remarks on result:

other: Conc.in environment / dose:0,04 mg/l

Any other information on results incl. tables

An increase of the BCF during the time could not be shown. The authors guess that steady-state was already reached within the first seven days of testing. The depuration phase was not studied.