Registration Dossier
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EC number: 204-428-0 | CAS number: 120-82-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Bioaccumulation: aquatic / sediment
Administrative data
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: OECD-Guideline study with acceptable restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
Materials and methods
Test guideline
- Qualifier:
- according to
- Guideline:
- OECD Guideline 305 C (Bioaccumulation: Test for the Degree of Bioconcentration in Fish)
- Deviations:
- yes
- Remarks:
- 1.) concentration of test substance differed more than 20% of the mean of the measured values 2.) the lipid content of fish was only determined at the end of the test
- GLP compliance:
- yes
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- - Name of test material (as cited in study report): 1,2,4-Trichlorbenzol
- Analytical purity: 98,1 %
- Impurities (identity and concentrations): no data
- Radiolabelling:
- no
Test organisms
- Test organisms (species):
- Cyprinus carpio
Study design
- Route of exposure:
- aqueous
- Test type:
- flow-through
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 56 d
Test conditions
- Nominal and measured concentrations:
- theoretic concentration in test chamber [mg/l] measured concentration in test chamber [mg/l]
0 (control) 0
0,01 0,00365
0,1 0,04165
Results and discussion
Bioaccumulation factoropen allclose all
- Type:
- BCF
- Value:
- 830
- Basis:
- whole body w.w.
- Remarks on result:
- other: Conc.in environment / dose:0,004 mg/l
- Type:
- BCF
- Value:
- 805
- Basis:
- whole body w.w.
- Remarks on result:
- other: Conc.in environment / dose:0,04 mg/l
- Type:
- BCF
- Value:
- 17 303
- Basis:
- total lipid content
- Remarks on result:
- other: Conc.in environment / dose:0,004 mg/l
- Type:
- BCF
- Value:
- 16 779
- Basis:
- total lipid content
- Remarks on result:
- other: Conc.in environment / dose:0,04 mg/l
Any other information on results incl. tables
An increase of the BCF during the time could not be shown. The authors guess that steady-state was already reached within the first seven days of testing. The depuration phase was not studied.
Applicant's summary and conclusion
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