Registration Dossier
Registration Dossier
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EC number: 204-428-0 | CAS number: 120-82-1
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
Data source
Reference
- Reference Type:
- publication
- Title:
- The liver, kidney, and thyroid toxicity of chlorinated benzenes.
- Author:
- den Besten C, Vet JJRM, Besselink HT, Kiel GS, van Berkel BJM, Beems R, van Bladeren PJ
- Year:
- 1 991
- Bibliographic source:
- oxicol Appl Pharmacol 111(1): 69–81
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,2,4-trichlorobenzene
- EC Number:
- 204-428-0
- EC Name:
- 1,2,4-trichlorobenzene
- Cas Number:
- 120-82-1
- Molecular formula:
- C6H3Cl3
- IUPAC Name:
- 1,2,4-trichlorobenzene
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Doses:
- 181,5; 362,9 or. 725,8 mg 1,2,4-Trichlorbenzol/kg KG
- No. of animals per sex per dose:
- 4
- Control animals:
- yes
Results and discussion
- Clinical signs:
- Were checked every 24hrs
- Body weight:
- Was checked every 24hrs
- Other findings:
- Blood was checked every 24hrs
Applicant's summary and conclusion
- Executive summary:
All exposed animals had lower body weight and higher liver weight after 72hr. In the epithelial cells of the proximal tubules protein droplets were detected. Further the thyroxine values were significantly lower in the blood plasma of the exposed animals 24hrs after the exposure.
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