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Physical & Chemical properties

Partition coefficient

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Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well documented publication which meets basic scientific principles. Adopted according to EU Risk Assessment (public available peer reviewed source).

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Determination of octanol/water partition coefficients for hydrophobic organic chemicals with the "slow-stirring" method
Author:
de Bruijn J et al.
Year:
1989
Bibliographic source:
Environ. Toxicol. Chem. 8, 499-512
Reference Type:
secondary source
Title:
Unnamed
Year:
2003
Reference Type:
secondary source
Title:
Critical evaluation of the measurement of the 1-octanol/water partition coefficient of hydrophobic compounds
Author:
Chessells M et al.
Year:
1991
Bibliographic source:
Chemosphere, 22(12), 1175-1190

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 123 (Partition Coefficient (1-Octanol / Water), Slow-Stirring Method)
Deviations:
yes
Remarks:
: following values were not reported: Exact volumes of 1-octanol and water, exact volumes of the samples, exact concentrations of the test substance in water and octanol, number of replicates, concentrations as function of time.
GLP compliance:
not specified
Type of method:
other: slow-stirring method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 1,2,4-Trichlorobenzene
- Analytical purity as cited: highest purity available, used for analysis without further purification

Study design

Analytical method:
other: GC or HPLC

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
4.05
Temp.:
25 °C
Details on results:
log Pow: 4.050 +/- 0.018

Any other information on results incl. tables

No further data on pH value.

Applicant's summary and conclusion

Executive summary:

de Bruijn J, 1989

Octanol/water partition coefficient for 1,2,4-trichlorobenzene was determined with the "slow-stirring" method similiar to OECD 123.

log Pow of 1,2,4-trichlorobenzene: 4.050 +/- 0.018 at 25°C.