Registration Dossier

Ecotoxicological information

Short-term toxicity to fish

Currently viewing:

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
not given
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: National Guideline study with acceptable restrictions, basic data given, only 48 h value reported

Data source

Reference
Reference Type:
publication
Title:
Ergebnisse der Untersuchungen von chemischen Stoffen mit vier Biotests.
Author:
Knie J, Haelke A, Juhnke I, Schiller W
Year:
1983
Bibliographic source:
Deutsche Gewässerkundliche Mitteilungen, 27(3), 77-79.

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: DIN 38412-15
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 1,2,4-Trichlorbenzol
- Analytical purity: not given

Test solutions

Vehicle:
not specified
Details on test solutions:
PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: DIN 38412 Teil 15

Test organisms

Test organisms (species):
Leuciscus idus
Details on test organisms:
TEST ORGANISM
- Common name (German): Goldorfe

Study design

Test type:
static
Water media type:
freshwater
Total exposure duration:
48 h

Results and discussion

Effect concentrationsopen allclose all
Duration:
48 h
Dose descriptor:
LC0
Effect conc.:
0.6 mg/L
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
0.7 mg/L
Duration:
48 h
Dose descriptor:
LC100
Effect conc.:
0.8 mg/L

Applicant's summary and conclusion

Validity criteria fulfilled:
not specified
Executive summary:

Knie et al. (1983)

This study reports the most critical and valid published LC50 for short term toxicity of 1,2,4 -TCB to fish. The study was performed in accordance to the National German Guideline DIN 38412 -15. Unfortunately the publication doesn't provide detailed information on test method. The very low LC50 of 0,7 mg/l after 48 hours of testing reveals a very high short term toxicity of 1,2,4 -TCB to fish. For this reason 1,2,4 -TCB is classified as "very toxic to aquatic organisms" (ATP 28).

Amongst others the study result of Knie et al. is cited as valid in the EU Risk Assessment Report (2003) and in the German BUA Report (1987) of 1,2,4 -TCB.