Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-087-7 | CAS number: 51-28-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Carcinogenicity
Administrative data
Description of key information
Two studies on dermal exposure were performed by skin painting on mice. 2,4-DNP was not effective as a tumor promotor.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Justification for classification or non-classification
Inconclusive
Additional information
In a study of Stenback F, Garcia H. 1975 three different experiment was performed. In the first experiment several applications by skin painting solution of 2,4- dinitrophenol in female mice, in combination with DMBA (Dimethylbenz(a)anthracene), acetone and croton oil as promoter. The treatment with the promotor 7,12-dimethyl-1,2-benzanthracene (DMBA) in acetone developed skin tumors in 23 of 30 mice (18 of 30 had papillomas an 12 of 30 had squamous cell carcinomas).In a second experiment: A single dose of 100 µg of 7,12-dimethyl-1,2-benzanthracene (DMBA) followed by application of other compounds or in a combination of other compounds were applied to female Swiss mice twice for 50 weeks. No squamous cell carcinomas were induced by any of these treatment. The incidence of papillomas was essentially no different or lower in mice receiving DMBA followed by 2,4-DNP and acetone, compared with mice receiving DMBA followed by acetone alone, and in mice receiving DMBA followed by 2,4-DNP and croton oil, compared with mice receiving DMBA followed by croton oil alone, 2,4-DNP did not appear to be a promoter for DMBA. In the third experiment, 2,4-DNP was applied after initiation with DMBA, followed by promotion with croton oil. 2,4-DNP was applied 2 days before initiation with DMBA, during initiation, and 2 days after initiation, followed by promotion with croton oil. The incidence of papillomas was 32 of 50 in this group compared with 30 of 50 in the group receiving DMBA alone followed by croton oil. 2,4-DNP had no significant influence on DMBA initiation of tumors promoted by croton oil.
In another study (Boutwell RK, Bosch DK. 1959), a single application of initiator 9,10-dimethyl-1,2-benzanthracene (DMBA); After, the test substance 2,4-dinitrophenol was applied to the same area of the initiator twice weekly for 12 weeks (time-weighted average (TWA) dose= 80 mg/Kg/day). Other animals were similar treated only with phenols. The survival rate after treatment with 2,4 -dinitrophenol was 100%. No evidence of skin papillomas or carcinomas was observed. As indicated in the study, 2,4-dinitrophenol is clearly not effective as a tumor promotor. The authors concluded that the introduction of nitro groups into the phenol ring destroyed the promoting effect of phenol, and that 2,4-DNP was not effective as a tumor promotor. 2,4-DNP was not tested as an initiator.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
