Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-087-7 | CAS number: 51-28-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data have been obtained from secondary source.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 995
- Reference Type:
- review article or handbook
- Title:
- Toxicological studies on laboratory animals of certain alkyldinitrophenols used in agriculture.
- Author:
- Spencer HC, Rowe VK, Irish DD.
- Year:
- 1 948
- Bibliographic source:
- J Ind Hyg Toxicol 30:10-25, 1948
Materials and methods
- Principles of method if other than guideline:
- Guinea pigs were exposed dermally to 100-1,000 mg/kg 2,4-dinitrophenol for 4 hours.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,4-dinitrophenol
- EC Number:
- 200-087-7
- EC Name:
- 2,4-dinitrophenol
- Cas Number:
- 51-28-5
- Molecular formula:
- C6H4N2O5
- IUPAC Name:
- 2,4-dinitrophenol
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Duration of exposure:
- 4 hours
- Doses:
- To 100-1000 mg/kg of 2,4-dinitrophenol
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD0
- Effect level:
- ca. 100 - 200 other: mg/kg
- Sex:
- not specified
- Dose descriptor:
- other: LD20
- Effect level:
- 300 other: mg/kg
- Sex:
- not specified
- Dose descriptor:
- LD100
- Effect level:
- 700 other: mg/kg
- Sex:
- not specified
- Dose descriptor:
- other: LOAEL
- Effect level:
- 300 other: mg/kg
Any other information on results incl. tables
No mortality was observed at 100 -200 mg/kg.
The lowest dose causing mortality LD20 was 300 mg/kg (20 %)
The lowest dose causing totally the mortality LD100 was 700 mg/kg (100%).
Due to the local effect it might be possible to identify a LOAEL of 300 mg/kg.
Applicant's summary and conclusion
- Conclusions:
- No mortality was observed at 100 or 200 mg/kg. LD20 was 300 mg/kg (20% mortallity ), and the lowest dose causing 100% mortality was 700 mg/kg.
Due to the local effect it might be possible to identify a LOAEL of 300 mg/kg. - Executive summary:
Data have been obtained from secondary source tha mentions Spencer HC, Rowe VK, Irish DD. 1948. Toxicological studies on laboratory animals of certain alkyldinitrophenols used in agriculture. J Ind Hyg Toxicol 30:10-25.Guinea pigs were exposed dermally to 100-1,000 mg/kg 2,4-DNP for 4 hours. No mortality was observed at 100 or 200 mg/kg. The lowest dose causing mortality at 20% was 300 mg/kg, and the lowest dose causing 100% mortality was 700 mg/kg. Due to the local effect it might be possible to identify a LOAEL of 300 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
