Registration Dossier
Registration Dossier
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EC number: 200-087-7 | CAS number: 51-28-5
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data have been obtained from secondary source.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 995
- Reference Type:
- review article or handbook
- Title:
- Mutagenicity of some commercially available nitro compounds
- Author:
- Chiu CW, Lee LH, Wang CY, et al.
- Year:
- 1 978
- Bibliographic source:
- Mutat Res 58:l l-22
Materials and methods
- Principles of method if other than guideline:
- Method included an in vitro test, without metabolic activation by rat liver S9 microsomes on Salmonella Thyphimurum. Details on method have not been specified.
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 2,4-dinitrophenol
- EC Number:
- 200-087-7
- EC Name:
- 2,4-dinitrophenol
- Cas Number:
- 51-28-5
- Molecular formula:
- C6H4N2O5
- IUPAC Name:
- 2,4-dinitrophenol
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium, other: TA98, TA100
- Metabolic activation:
- without
- Metabolic activation system:
- rat liver S9 microsomes
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other: TA98, TA100
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative without metabolic activation
In vitro study for reverse mutation on Salmonella Thypimurium, strain TA98, TA100, without rat liver S9 metabolic activation is negative. - Executive summary:
Data have been obtaioned from a secondary source, that mentions Chiu CW, Lee LH, Wang CY, et al. 1978. Mutagenicity of some commercially available nitro compounds. Mutat Res 58:l l-22. An in vitro study of reverse mutation on procariotic organism Salmonella Thypimurium, strain TA98, TA100 was performed without rat liver S9 microsomes metabolic activation.
The results show that 2,4 -dinitrophenol is negative for reverse mutation test.
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