Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-087-7 | CAS number: 51-28-5
Toxicity to reproduction
Administrative data
- Endpoint:
- toxicity to reproduction
- Remarks:
- other: testicular observation (after ingestion of capsules)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data have been obtained from secondary source.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 995
- Reference Type:
- review article or handbook
- Title:
- 1934b. Di-nitrophenol. Studies of blood, urine, and tissues of dogs on continued medication and after acute fatal poisoning.
- Author:
- Tainter ML, Cutting WC, Wood DA, et al.
- Year:
- 1 934
- Bibliographic source:
- Arch Pathol 18:881.
Materials and methods
- Principles of method if other than guideline:
- The method was based on an exposure to dogs via capsules of 2,4-dinitrophenol for six months. No further details were specified.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,4-dinitrophenol
- EC Number:
- 200-087-7
- EC Name:
- 2,4-dinitrophenol
- Cas Number:
- 51-28-5
- Molecular formula:
- C6H4N2O5
- IUPAC Name:
- 2,4-dinitrophenol
Constituent 1
Test animals
- Species:
- other: dog
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: capsules
- Duration of treatment / exposure:
- six months
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
5 mg/kg/day
Basis:
other: in capsules
- Remarks:
- Doses / Concentrations:
10 mg/Kg/day
Basis:
other: in capsules
- No. of animals per sex per dose:
- 3 per dose group
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
- Dose descriptor:
- NOAEL
- Effect level:
- 10 other: capsules
- Sex:
- male
- Remarks on result:
- other: no futher information available
Results: F1 generation
Effect levels (F1)
- Remarks on result:
- not measured/tested
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
No gross histological evidence of treatment-related testicular damage was reported following 2,4-dinitrophenol at 5 or 10 mg/Kg/day.
Applicant's summary and conclusion
- Conclusions:
- No gross histological evidence of treatment-related testicular damage was reported following 2,4-dinitrophenol at 5 or 10 mg/Kg/day.
- Executive summary:
Data have been obtained from secondary source that mentions Tainter ML, Cutting WC, Wood DA, et al. 1934b. Di-nitrophenol. Studies of blood, urine, and tissues of dogs on continued medication and after acute fatal poisoning. Arch Pathol 18:881. The method was based on an exposure to dogs via capsules of 2,4-dinitrophenol for six months. No further details were specified.
Testicular tissue vas histologically analysed after the 2,4 -dinitrophenol exposure and no gross histological evidence of treatment-related testicular damage. No gross histological evidence of treatment-related testicular damage was reported following 2,4-dinitrophenol at 5 or 10 mg/Kg/day.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
