2,4-dinitrophenol

Repeated dose toxicity: oral

Administrative data

Endpoint:

short-term repeated dose toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Data has been obtained from secondary source.

Data source

Reference

Reference 1

Reference Type:

secondary source

Title:

Unnamed

Year:

1995

Reference 2

Reference Type:

study report

Title:

Unnamed

Year:

1964

Materials and methods

Principles of method if other than guideline:

Method has not been specified. The study is considered reasonably well conducted.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

2,4-dinitrophenol

EC Number:

200-087-7

EC Name:

2,4-dinitrophenol

Cas Number:

51-28-5

Molecular formula:

C6H4N2O5

IUPAC Name:

2,4-dinitrophenol

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

oral: feed

Duration of treatment / exposure:

4 weeks

Results and discussion

Effect levels

Dose descriptor:

NOAEL

Effect level:

59 mg/kg diet

Sex:

not specified

Remarks on result:

other: no further information available

Target system / organ toxicity

Critical effects observed:

not specified

Any other information on results incl. tables

No mortality LD0 was observed at dose <= 59 mg/Kg/day. A NOAEL of 59 mg/kg/day was determinated because food consumption and body weight gain in rats exposed to that dose of 2,4 -dinitrophenol in the diet for 4 weeks were similar to those of controls.

Applicant's summary and conclusion

Conclusions:

LD0 was observed at dose <= 59 mg/Kg/day.
A NOAEL of 59 mg/kg/day was observed for food consumption and body weight gain.

Executive summary:

Data has been obtained from secondary source that mentions Kaiser JA. 1964. Studies on the toxicity of diisophenol (2,6-diiodo-4-nitrophenol) to dogs and rodents plus some comparison with 2,4-dinitrophenol. Toxicol Appl Pharmacol 6:232-244.

Weanling rats were exposed to 2,4 -dinitrophenol in the feed for 4 weeks. No mortality LD0 was observed at dose <= 59 mg/Kg/day. A NOAEL of 59 mg/kg/day was determined because food consumption and body weight gain in rats exposed to that dose of 2,4 -dinitrophenol in the diet for 4 weeks were similar to those of controls.

Method has not been specified but the study is considered reasonably well conducted.