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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1977
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Pre-GLP; short report, limited documentation

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report Date:
1977

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
not specified
GLP compliance:
no
Remarks:
pre dates GLP
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
slightly yelow scales

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals and environmental conditions:
Strain: WISKf (SPF 71)
Weight range: 186-226 g; mean 209 g;

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: sesame oil
Details on oral exposure:
5% solution in sesame oil
Doses:
250-400-630-800-1000-1600 mg/kg
No. of animals per sex per dose:
10
Control animals:
no
Statistics:
determination of LD50 by probit analysis

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
ca. 939 mg/kg bw
95% CL:
>= 816 - < 1 130
Mortality:
Dose / # of dead animals of 10
250 / 0
400 / 0
630 / 1
800 / 3
1000 / 5
1600 / 10
Clinical signs:
Animals died with 50 minutes to 5 days. Clincal signs in moribung animals were: prostration, reduced motoractivity, pnosis, convulsions (pre-mortal). At 1600 mg/kg additionally a sqatting posture, piloerection, increased sensitivity to noise, and tonic and clonic convulsions were observed
Body weight:
no data
Gross pathology:
dead animals: discolored lungs, brownish blood (methemogolgin), orange discolored urine,
survivors: peritonitis with adhesions among the abdominal organs; purulent, ulcerative inflammation of the stomach lining; in some cases perforation of the stomach wall.

Applicant's summary and conclusion

Interpretation of results:
moderately toxic
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
The LD 50 after oral gavage in a 5% oily solution to male rats was 939 mg/kg bw