Registration Dossier
Registration Dossier
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EC number: 202-551-4 | CAS number: 97-00-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: tabular report of results, pre-dates GLP regulations, short report, few methodological details
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 962
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- range finding test
- GLP compliance:
- no
- Remarks:
- pre dates GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1-chloro-2,4-dinitrobenzene
- EC Number:
- 202-551-4
- EC Name:
- 1-chloro-2,4-dinitrobenzene
- Cas Number:
- 97-00-7
- Molecular formula:
- C6H3ClN2O4
- IUPAC Name:
- 1-chloro-2,4-dinitrobenzene
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
Administration / exposure
- Type of coverage:
- other: using a "cuff"; probaly occlusive, but not defintely described
- Vehicle:
- not specified
- Duration of exposure:
- 24 hours
- Doses:
- no data
- No. of animals per sex per dose:
- 4
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 130 mg/kg bw
- 95% CL:
- > 80 - < 190
- Remarks on result:
- other: Level of confidence not reported
- Mortality:
- no data
- Clinical signs:
- other: no data
- Gross pathology:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The LD 50 of DNCB after dermal application to rabbits for 24 h was ca. 130 mg/kg bw.
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