Registration Dossier

Toxicological information

Additional toxicological data

Currently viewing:

Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1989
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Standard test, conforms to GLP; limited information (no information on exposure duration and methods)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1989
Report Date:
1989

Materials and methods

Principles of method if other than guideline:
cells were exposed in presence and absence of S0 mix and cell survival was determined after

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
purity: 99,9 %
yellow crystals

Results and discussion

Any other information on results incl. tables

In the absence of a metabolic activation system DNCB was toxic to V 79 cells at all tested concentrations (0,5 - 2025 µg/ml). Even at the lowest tested concentration only about 5 % of the seeded cells survived. Addition of a metabolic system increased the lowest toxic

dose to 10 µg/ml (44.7% survival)

Applicant's summary and conclusion

Conclusions:
DNCB was highly toxic ine presence and absence of an activation system to V79 cells in vitro.