Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: few details, short publication, method of 1959

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1959

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Rats were treated by intraperitopneal injection
GLP compliance:
no
Remarks:
predates GLP

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
chemically pure test substance

Test animals

Species:
rat
Strain:
not specified
Sex:
female
Details on test animals and environmental conditions:
no data

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: aqueous suspension containing 10% gum arabic
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
ca. 280 mg/kg bw

Any other information on results incl. tables

Dose range: 120 - 940 mg/kg

Findings: signs of pain, agitation, no food intake, uncotrolled urination, reduction of body weight, in moribund animals: tonic and clonic convulsions. Death occurred within less than 1 h.

Applicant's summary and conclusion