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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: No quantitative data, no strutural nformation regarding the measured metabolites

Data source

Reference
Reference Type:
publication
Title:
Toxicity of and biological monitoring for 1,3-Diamino-2,4,6-trinitrobenzene and other nitro-amino derivatives of benzene and chlorobenzene
Author:
Watanabe, T.; Ishihara, N.; Ikeda, M.
Year:
1976
Bibliographic source:
Int. Arch. Occup. Environ. Hlth. 37,, 157-168 (1976)

Materials and methods

Objective of study:
other: development of a method for biomonitoring
Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
A method for qualitative detection of test substance / metabolites was developed
GLP compliance:
no
Remarks:
predates GLP

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data, except the name
Radiolabelling:
no

Test animals

Species:
rat
Strain:
Wistar
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
propylene glycol
Duration and frequency of treatment / exposure:
single injection
Doses / concentrations
Remarks:
Doses / Concentrations:
100µMol/kg bw ( 20,256 mg/kg bw
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on excretion:
DNCB and/ or metabolites are excreted via uriine in the rat.

Metabolite characterisation studies

Metabolites identified:
no

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): bioaccumulation potential cannot be judged based on study results
DNCB is excreted via urine in the rat.