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EC number: 807-840-4
CAS number: 64896-70-4
28-day toxicity in the rat by the oral route followed by a 14-day recovery period: NOAEL = 2000 mg/kg bw/d (with the analogous substance DEI)13-week oral toxicity study in the rat including recovery and TK: NOAEL = 2000 mg/kg bw/d (with the analogous substance DEI)
There is no data available on the test
item, but the repeated dose toxicity of DOI was assessed by analogy with
DEI was tested for oral repeated dose
toxicity in rat according to OECD guideline 407 (4 weeks) and according
to OECD 408 (13 weeks). Under the experimental conditions, DEI
administered at the doses of 0.5, 1 and 2 g of DEI/kg for 4 or 13 weeks
did not induce any sign of toxicity. Therefore, the No-Observed-Adverse
Effect Level (NOAEL) of DEI is equal to 2 g of DEI/kg.
with DEI, based on the classification criteria of Annex VI Directive
67/548/EEC or UN/EU GHS, and given the absence of signs of toxicity up
to the highest dose of 2000 mg/kg bw/d administered in rats by gavage
during 4 and 13 weeks, no classification for repeat-dose toxicity is
warranted according to the criteria of Annex VI Directive 67/548/EEC or
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